Metabolic Consequence of Short Term Starvation

The metabolic consequences of preoperative starvation and carbohydrate loading and mechanisms linking insulin resistance to impaired mitochondrial function are discussed. We just find out the short-term energy deprivation combinations with the health control subject. Followed by the nutrition and metabolism on molecular basis of per operative surgery. Majority of animal studies have shown that short-term energy deprivation decreases mitochondrial ATP synthesis capacity and complex activity, and increases oxidative injury which lead to development of insulin resistance (IR) during starvation and associated with an impaired mitochondrial function. From animal to human subject we thoroughly find out that short-term starvation (STS) causes mitochondrial dysfunction and it underlies the development of insulin resistance (IR) in patients undergoing elective surgery (ES).